PROF. QI-LIN ZHOU

State Key Laboratory of Elemento-

organic Chemistry

Nankai University

Weijin Rd. 94, Tianjin 300071

P. R. CHINA

Phone: 86-22-2350 0011

Fax: 86-22-2350 6177

E-mail: qlzhou@nankai.edu.cn

Research Group Home Page: http:// zhou.nankai.edu.cn/

 

EDUCATION:

1982-1987    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, CHINA. Received Ph.D. degree in December, 1987 (with Prof. Yao-Zeng Huang).

1978-1982    Department of Chemistry, Lanzhou University, Lanzhou, CHINA. Received B. Sc. Degree in June, 1982.

 

ACADEMIC CAREER:

2004-            Director, State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2004-            Director, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

1999-            Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

1996-1999    Professor, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, CHINA.

1994-1996    Postdoctoral associate, Department of Chemistry, Trinity University, Texas, U.S.A. (with Prof. Michael P. Doyle).

1992-1994    Postdoctoral associate, Institute of Organic Chemistry, Basel University, Basel, SWITZERLAND (with Prof. Andreas Pfaltz).

1990-1992    Postdoctoral associate, Max-Planck Institute of Polymer Science, Mainz, GERMANY (with Prof. Klaus Muellen).

1988-1990    Postdoctoral associate, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, CHINA (with Prof. Zheng-Hua Zhu).

 

RESEARCH AREAS:

(1) Development of new synthetic methods.

(2) Organometallic chemistry directed towards organic synthesis.

(3) Asymmetric catalysis.

(4) Synthesis of biologically active natural and unnatural products.

 

HONORS AND AWARDS

2010      Morningside Lectureship

2009      Member of Chinese Academy of Sciences

2008      PKU-Lilly Lectureship

2007      Prize of Natural Science of Tianjin (1st class)

2007      JSPS Fellow (Japan Society for the Promotion of Science)

2006      Yao-Zeng Huang Prize for Organometallic Chemistry (Chinese Chemical Society)

2005      Prize for Creation in Organic Synthesis (Chinese Chemical Society, Division of Organic Chemistry)

1999      Cheung Kong Scholar (Ministry of Education of China)

1997      Award for National Outstanding Young Scientist (National Natural Science Foundation of China)

 

EDITORAL BOARDS

2011-     Member, Editoral Board of Organic & Biomolecular Chemistry.

2011-     Member, Editorial Board of Advanced Synthesis & Catalysis.

2011-     Member, Editorial Advisory Board of ACS Catalysis.

2010-     Member, Editorial Advisory Board of Chemical Science.

2009-     Member, Editorial Advisory Board of Accounts of Chemical Research.

2009-     Member, Board of Series Editors of Topics in Organometallic Chemistry.

2008-     Member, Editorial Board of Journal of Molecular Catalysis A: Chemical.

2007-     Member, Editorial Board of Chemical Journal of Chinese University.

2007-     Member, Editorial Board of Chinese Journal of Organic Chemistry.

2005-     Member, Editorial Board of Frontiers of Chemistry in China

              Selected Publications from Chinese Universities.

2003-     Member, Editorial Board of Science in China, Chemistry.

 

SELECTED PUBLICATIONS

1            Jian-Hua Xie*, Xiao-Yan Liu, Jian-Bo Xie, Li-Xin Wang, Qi-Lin Zhou*, Additional coordination group leads to extremely efficient chiral iridium catalysts for asymmetric hydrogenation of simple ketones, Angew. Chem. Int. Ed. 2011, 50, 7329-7332.

2            Qiu-Shi Wang, Jian-Hua Xie, Wei Li, Shou-Fei Zhu, Li-Xin Wang, Qi-Lin Zhou*, Ruthenium-catalyzed hydrovinylation of N-acetyl enamines leading to amines with an a-quaternary carbon center, Org. Lett. 2011, 13, 3388-3391.

3            Shou-Fei Zhu, Xiang-Chen Qiao, Yong-Zhen Zhang, Li-Xin Wang, Qi-Lin Zhou*, Highly enantioselective palladium-catalyzed umpolung allylation of aldehydes, Chem. Sci. 2011, 2, 1135–1140.

4            Shou-Fei Zhu, Wan-Qiao Chen, Qian-Qian Zhang, Hong-Xiang Mao, Qi-Lin Zhou*, Enantioselective copper-catalyzed O–H insertion of α-diazo phosphonates, Synlett  2011, 919-922.

5            Jian-Hua Xie, Shou-Fei Zhu, Qi-Lin Zhou*, Transition metal-catalyzed enantioselective hydrogenation of enamines and imines, Chemical Reviews 2011, 111, 1713-1760.

6            Jian-Bo Xie, Jian-Hua Xie*, Xiao-Yan Liu, Qian-Qian Zhang, Qi-Lin Zhou*, Chiral iridium spiro aminophosphine complexes: asymmetric hydrogenation of simple ketones, structure and plausible mechanism, Chem. Asian J. 2011, 6, 899-908.

7            Shou-Fei Zhu, Xiao-Guang Song, Yu Li, Yan Cai, Qi-Lin Zhou*, Enantioselective copper-catalyzed intramolecular OH bond insertion: An efficient approach to chiral 2-carboxy cyclic ethers, J. Am. Chem. Soc. 2010, 132, 16374-16376.

8            Chang-Yue Zhou, Shou-Fei Zhu, Li-Xin Wang, and Qi-Lin Zhou*, Enantioselective nickel-catalyzed reductive coupling of alkynes and imines, J. Am. Chem. Soc. 2010, 132, 10955-10957.

9            Jian-Bo Xie, Jian-Hua Xie*, Xiao-Yan Liu, Wei-Ling Kong, Shen Li, and Qi-Lin Zhou*, Highly enantioselective hydrogenation of a-arylmethylene cycloalkanones catalyzed by iridium complexes of chiral spiro aminophosphine ligands, J. Am. Chem. Soc. 2010, 132, 4538-4539.

10        Shen Li, Shou-Fei Zhu, Jian-Hua Xie, Song Song, Can-Ming Zhang, Qi-Lin Zhou*, Enantioselective hydrogenation of a-aryloxy and a-alkoxy a,β-unsaturated carboxylic acids catalyzed by chiral spiro iridium/phosphino-oxazoline complexes, J. Am. Chem. Soc. 2010, 132, 1172-1179.

11        Shou-Fei Zhu, Yan Cai, Hong-Xiang Mao, Jian-Hua Xie, Qi-Lin Zhou*, Enantioselective iron-catalyzed OH bond Insertions, Nature Chemistry 2010, 2, 546-551.

12        Wen-Ju Bai, Jian-Hua Xie, Ya-Li Li, Sheng Liu, Qi-Lin Zhou*, Enantioselective synthesis of chiral b-aryloxyalcohols by ruthenium-catalyzed ketone hydrogenation via DKR, Adv. Synth. Catal. 2010, 352, 81-84.

13        Pu-Cha Yan, Jian-Hua Xie, Guo-Hua Hou, Li-Xin Wang, Qi-Lin Zhou*, Enantioselective synthesis of chiral tetrahydroisoquinolines by iridium-catalyzed asymmetric hydrogenation of enamines, Adv. Synth. Catal. 2009, 351, 3243-3250.

14        Zhang-Tao Zhou, Jian-Hua Xie, Qi-Lin Zhou*, Enantioselective synthesis of chiral α-aryloxy alcohols by asymmetric hydrogenation of α-aryloxy aldehydes via dynamic kinetic resolution, Adv. Synth. Catal. 2009, 351, 363-366.

15        Sheng Liu, Jian-Hua Xie, Wei Li, Wei-Ling Kong, Li-Xin Wang, Qi-Lin Zhou*, Highly enantioselective synthesis of chiral cyclic amino alcohols and conhydrine by ruthenium-catalyzed asymmetric hydrogenation, Org. Lett. 2009, 11, 4994-4997.

16        Yong-Zhen Zhang, Shou-Fei Zhu, Yan Cai, Hong-Xiang Mao, Qi-Lin Zhou*, Copper-catalyzed enantioselective carbenoid insertion into S–H bonds, Chem. Commun. 2009, 5362-5364.

17        Jian-Hua Xie, Sheng Liu, Wei-Ling Kong, Wen-Jun Bai, Xiao-Chen Wang, Li-Xin Wang, Qi-Lin Zhou*, Highly enantioselective and diastereoslective synthesis of chiral amino alcohols by ruthenium-catalyzed asymmetric hydrogenation of a-amino aliphatic ketones, J. Am. Chem. Soc. 2009, 131, 4222-4223.

18        Guo-Hua Hou, Jian-Hua Xie, Pu-Cha Yan, Qi-Lin Zhou*, Iridium-catalyzed asymmetric hydrogenation of cyclic enamines, J. Am. Chem. Soc. 2009, 131, 1366-1367.

19        Jian-Hua Xie, Qi-Lin Zhou*, Chiral diphosphine and monodentate phosphorus ligands on a spiro scaffold for transition-metal-catalyzed asymmetric reactions, Acc. Chem. Res. 2008, 41, 581-593.

20        Yun Yang, Shou-Fei Zhu, Chang-Yue Zhou, Qi-Lin Zhou*, Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins, J. Am. Chem. Soc. 2008, 130, 14052-14053.

21        Shen Li, Shou-Fei Zhu, Can-Ming Zhang, Song Song, Qi-Lin Zhou*, Iridium-catalyzed enantioselective hydrogenation of α,b-unsaturated carboxylic acids, J. Am. Chem. Soc. 2008, 130, 8584-8585.

22        Hai-Feng Duan, Jian-Hua Xie, Xiang-Chen Qiao, Li-Xin Wang, Qi-Lin Zhou*, Enantioselective rhodium-catalyzed addition of arylboronic acids to α-ketoesters, Angew. Chem. Int. Ed. 2008, 47, 4351-4353.

23        Yong-Zhen Zhang, Shou-Fei Zhu, Li-Xin Wang, Qi-Lin Zhou*, Copper-catalyzed highly enantioselective carbenoid insertion into SiH Bonds, Angew. Chem. Int. Ed. 2008, 47, 8496-8498.

24        Shou-Fei Zhu, Chao Chen, Yan Cai, Qi-Lin Zhou*, Catalytic asymmetric reaction with water: Enantioselective synthesis of α-hydroxyesters by copper-carbenoid O–H insertion reaction, Angew. Chem. Int. Ed. 2008, 47, 932-934.

25        Liang Xing, Jian-Hua Xie, Yong-Sheng Chen, Li-Xin Wang, Qi-Lin Zhou*, Simply modified chiral diphosphine: catalyst recycling via non-covalent absorption on carbon nanotubes, Adv. Synth. Catal. 2008, 350, 1013-1016.

26        Qi Zhang, Shou-Fei Zhu, Xiang-Chen Qiao, Li-Xin Wang, Qi-Lin Zhou*, Nickel-catalyzed highly selective hydrovinylation of α-ketals of vinylarenes, Adv. Synth. Catal. 2008, 350, 1507-1510.

27        Wei Zhang, Shou-Fei Zhu, Xiang-Chen Qiao, Qi-Lin Zhou*, Highly enantioselective copper-catalyzed ring opening of oxabicyclic alkenes with Grignard reagents, Chem. Asian J. 2008, 3, 2105-2111.

28        Chao Chen, Shou-Fei Zhu, Bin Liu, Li-Xin Wang, Qi-Lin Zhou*, Highly enantioselective insertion of carbenoids into O–H bonds of phenols: An efficient approach to chiral α-aryloxycarboxylic esters, J. Am. Chem. Soc. 2007, 129, 12616-12617.

29        Bin Liu, Shou-Fei Zhu, Wei Zhang, Chao Chen, Qi-Lin Zhou*, Highly enantioselective insertion of carbenoids into N-H bonds catalyzed by copper complexes of chiral spiro bisoxazolines, J. Am. Chem. Soc. 2007, 129, 5834-5835.

30        Yun Yang, Shou-Fei Zhu, Hai-Feng Duan, Chang-Yue Zhou, Li-Xin Wang, Qi-Lin Zhou*, Asymmetric reductive coupling of dienes and aldehydes catalyzed by nickel complexes of spiro phosphoramidites: Highly enantioselective synthesis of chiral bishomoallylic alcohols, J. Am. Chem. Soc. 2007, 129, 2248-2249.

31        Jian-Hua Xie, Zhang-Tao Zhou, Wei-Ling Kong, Qi-Lin Zhou*, Ru-Catalyzed asymmetric hydrogenation of racemic aldehydes via dynamic kinetic resolution: efficient synthesis of optically active primary alcohols, J. Am. Chem. Soc. 2007, 129, 1868-1869.

32        Bao-Min Fan, Jian-Hua Xie, Shen Li, Li-Xin Wang, Qi-Lin Zhou*, Highly enantioselective silylcarbocyclization of 1,6-enynes catalyzed by Rh(I)-SDP complexes, Angew. Chem. Int. Ed. 2007, 46, 1275-1277.

33        Yi-Xia Jia, Jun Zhong, Shou-Fei Zhu, Can-Ming Zhang, Qi-Lin Zhou*, Chiral Brønsted acid catalyzed enantioselective Friedel-Crafts reaction of indoles and α-aryl enamides: construction of chiral quaternary carbons, Angew. Chem. Int. Ed. 2007, 46, 5565-5567.

34        Sheng Liu, Jian-Hua Xie, Li-Xin Wang, Qi-Lin Zhou*, Dynamic kinetic resolution allows a highly enantioselective synthesis of cis-α-aminocycloalkanols by ruthenium-catalyzed asymmetric hydrogenation, Angew. Chem. Int. Ed. 2007, 46, 7506-7508.

35        Wen-Jian Shi, Qi Zhang, Jian-Hua Xie, Shou-Fei Zhu, Guo-Hua Hou, Qi-Lin Zhou*, Highly enantioselective hydrovinylation of α-alkyl vinylarenes. An approach to the construction of all-carbon quaternary stereocenters, J. Am. Chem. Soc. 2006, 128, 2780-2781.

36        Guo-Hua Hou, Jian-Hua Xie, Lin-Xin Wang, Qi-Lin Zhou*, Highly efficient Rh(I)-catalyzed hydrogenation of enamines using monodentate spiro phosphonite ligands, J. Am. Chem. Soc. 2006, 128, 11774-11775.

37        Shou-Fei Zhu, Jian-Bo Xie, Yong-Zhen Zhang, Shen Li, Qi-Lin Zhou*, Well-defined chiral spiro Ir/phosphine-oxazoline cationic complexes for highly enantioselective hydrogenation of imines at ambient pressure, J. Am. Chem. Soc. 2006, 128, 12886-12891.

38        Xu Cheng, Jian-Hua Xie, Sheng Li, Qi-Lin Zhou*, Ru(II)-SFDP complexes catalyzed asymmetric hydrogenation of a,b-unsaturated carboxylic acids, Adv. Synth. Catal. 2006, 348, 1271-1276.

39        Hai-Feng Duan, Jian-Hua Xie, Wen-Jian Shi, Qi Zhang, Qi-Lin Zhou*, Enantioselective rhodium-catalyzed addition of arylboronic acids to aldehydes using chiral spiro monophosphite ligands, Org. Lett. 2006, 8, 1479-1481.

40        Yi-Xia Jia, Jian-Hua Xie, Hai-Feng Duan, Li-Xin Wang, Qi-Lin Zhou*, Asymmetric Friedel–Crafts addition of indoles to N-sulfonyl aldimines: A simple approach to optically active 3-indolylmethanamine derivatives, Org. Lett. 2006, 8, 1621-1624.

41        Hai-Feng Duan, Yi-Xia Jia, Li-Xin Wang, Qi-Lin Zhou*, Enantioselecitive Rh-catalyzed arylation of N-tosylarylimines with arylboronic acids, Org. Lett. 2006, 8, 2567-2569.

42        Yi-Xia Jia, Shuo-Fei Zhu, Yun Yang, Qi-Lin Zhou*, Asymmetric Friedel–Crafts alkylations of indoles with nitroalkenes catalyzed by Zn(II)-bisoxazoline complexes, J. Org. Chem. 2006, 71, 75-80.